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Topiramate and M1 elimination half-lives (13 hrs. for Topiramate and 19 hrs. for M1).
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
Although Topiramate is known to exhibit a local anaesthetic effect, how Topiramate exerts this effect is not understood fully.
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Topiramate is administered as a racemate and both [-] and [+] forms of both Topiramate and M1 are detected in the circulation.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Topiramate and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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